Steer clear of coadministration with delicate CYP3A substrates. If coadministration unavoidable, check for adverse reactions and lessen CYP3A substrate dose in accordance with solution labeling.bosentan will lessen the level or impact of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Contraindicated (1)nir… Read More